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Beta-Caryophyllene

Chances are you have not only been exposed to beta-caryophyllene but actually enjoyed it at least once before in your life. If you’ve ever smelled spices that contained cloves or used freshly ground black pepper then you have encountered this chemical compound.

What you also may have not known is the wide array of benefits this adaptogen has to offer you. This article will take a look at what beta-caryophyllene is, how it helps provide stress support, and what side effects it may pose.

Non-habit forming
Natural active ingredients
Manufactured in USA
Caffeine Free
Non-drowsy
Melatonin Free

NSF certification helps consumers identify products that have been indepnedently tested and certified to meet rigorous standards for quality, safety, and label claims.

What is Beta-Caryophyllene?

Beta-caryophyllene is a bicyclic molecule that is associated with many essential oils. While it is most concentrated in clove derivatives, it can be found in many different kinds of seasonings, meals, and even drinks. Its spicy, warm scent is the flag marker for its presence and is present in most spice mixes and even common seasonings like black pepper, and found in hundreds of plants.

This is because beta-caryophyllene is a compound known as a terpene. These chemical compounds are aromatic and are responsible for most of the delicious smells that herbs are known for. Because of this, beta-caryophyllene can be harvested all over the planet. It also has unique properties as a terpene in that it can actually interact with cannabinoid receptors found inside our bodies.

Even though this compound can be commonly found in scents such as basil or even garlic, it has one special characteristic that makes it a powerful supplement for stress support. That characteristic comes from the cyclobutane ring in its molecular structure. This unique feature makes beta-caryophyllene a prime candidate to participate in many chemical reactions.

Let's take a look at how it interacts with one particular set of proteins known as endocannabinoid receptors.

How Does Beta-Caryophyllene Provide Stress Support?


Throughout your entire body you have a very unique set of receptors known as endocannabinoid receptors. These proteins are like switches for pathways that promote healing, mood change, and decrease of tension and can even elevate restlessness and promote calmness. These pathways are involved in a wealth of processes that promote overall health and stress support. 


These receptors and pathways are part of the endocannabinoid system, or ECS. The potential of this system to affect our entire bodies is vast. The receptor portion is divided into two classes called CB1 and CB2. The receptors are triggered, bound, or activated by endocannabinoids, a class of molecules that can interact with these receptors to initiate a chain of chemical reactions. 


The unique properties of beta-caryophyllene’s chemical structure actually make it able to interact with CB2 receptors in the ECS. The CB2 receptor is where the non-psychoactive endocannabinoid CBD binds. While the effects of this reaction are still being investigated, this receptor does not trigger any psychoactive effects but is associated with the soothing qualities of the ECS. 

Endocannabinoids can be produced by our own bodies and can also be consumed. THC, the active compound in marjauna responsible for its psychoactive effects, is an endocannabinoid that binds to the CB1 receptors. This receptor is correlated with the psychoactive effects of the ECS system and is responsible for what makes people feel “high.” 

In essence, beta-caryophyllene is a natural substance that can harness the benefits of the ECS and support system-wide wellness and relaxation but it doesn’t induce the controversial psychoactive effects that THC has on CB1 receptors.



What Else Can Beta-Caryophyllene Be Used For?

Beta-caryophyllene can be produced in a cream form for topical application. While the exact extent of the health benefits of such a topical solution is still under investigation, it is thought that this can act as a soothing agent to areas experiencing stress throughout the body.

As mentioned earlier, beta-caryophyllene is a common element in many substances that are associated with cooking. Cloves themselves provide a great source of beta-caryophyllene and it can be processed into an essential oil as well.


The team at R3SET has worked hard to take advantage of all of beta-caryophyllene’s stress-supporting benefits along with other powerful supplements like relora and L-theanine in our powerful Calm supplement. This supplement is a perfect example of how beta-caryophyllene can be utilized as a daily supplement to help encourage a peaceful, restful mind throughout the da

Average Dosing and Side Effects


You should always check with your Healthcare Provider before starting a new supplement if you have never taken beta-caryophyllene and have questions about its possible interactions with other medications or supplements you’re currently taking. 


Despite there being very few to no known side effects of beta-caryophyllene, you should also make sure that you are not allergic to this particular terpene, any natural form of cannabinoids, or food allergies that may contain beta-caryophyllene

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